Monday, 1 March 2021

SSBTR International Webinar Lecture Series Day: 2021 March 14 (Sunday) IST 13:45 Hour

 Society for Systems Biology & Translational Research (SSBTR) is a registered (and also both 12A & 80G certified) not-for-profit scientific society organizes an International Webinar Series Lectures on Translational Systems Biology.

All are cordially invited. For date, time and link and other details as below:

GOOGLE MEET Link: url (https://meet.google.com/qjb-utgp-ymk)

Day: 2021-March-14 (Sunday)    Time: IST 14:00 Hour

# Speaker: Dr. Milana Frenkel-Morgenstern
Title: Diagnosis of Glioma Tumors Using Circulating Cell-Free DNA

Abstract: Gliomas are the most frequent brain tumors, making up about 30% of all brain and central nervous system tumors, and 80% of all malignant brain tumors. Diagnosis of different glioma tumor types and their tumor grade is an essential step to suggest a right treatment for the glioma patients. Existing standard diagnostic technique for glioma tumor includes tissue biopsy, which is a highly invasive and hence a risky technique for the patient’s survival. ‘Liquid biopsy’ is a new and recently developed non-invasive cancer diagnostic technique. This technique includes collection of blood or urine samples and diagnosis of cancer based on analyzing molecular bits or cancer cells that are released from tumor tissue into the blood or urine system. Circulating cell-free DNA (cfDNA) fragments is one those molecular bits that are released into the bloodstream after rapid apoptosis or necrosis of the tumor cells in the cancer patients. Our goal is to do comprehensive study between distinct types of glioma cancer tumors and cfDNA of the respective patients, to elucidate the scope of cfDNA in liquid biopsy technique for glioma diagnosis. We have successfully detected glioma specific mutations such as IDH1, IDH2, PDGFRA, NOTCH1, PIK3R1 and TP53, from cfDNA isolated from the plasma of glioma patients and could relate these mutations to the different tumor grades of glioma. Moreover, we have identified unique gene-gene fusions that provide a personalized drug response to glioma treatment. Our study may help in developing liquid biopsy technique for glioma tumor diagnosis and in its prognosis for monitoring the glioma treatment by non-invasive approach, and will eventually help physicians to decide on the right treatment while bypassing the existing ''wait-and-see' approach of treatment monitoring.
Biosketch: Dr. Milana Frenkel-Morgenstern, Senior Lecturer and Head of Cancer Genomics and Bio-computing of Complex Diseases, Azrieli Faculty of Medicine,
Bar-Ilan University. She has completed her Ph.D in the Weizmann Institute of Science, Israel in 2006. She made her first postdoc in the lab of Prof. Uri Alon in Systems Biology in the Weizmann Institute of Science, Israel, and the second postdoc in the lab of Prof. Alfonso Valencia in the Spanish National Cancer Research Centre (CNIO), Spain. She has published more than 50 papers in reputed journals and serving as an editorial board member of repute. She is a founder of special scientific Art in Science competition at the international Bioinformatics conferences since 2008, a chair of the ISCB affiliated Israeli Bioinformatics group. Her group has developed unique protocols for the cell free DNA isolation and its analysis using unique and patented techniques, the group in working in evolution of protein interaction networks. 

Sunday, 24 January 2021

SSBTR International Webinar Lecture Series Day: 2021 February 27 (Saturday) IST 16:45 Hour

Society for Systems Biology & Translational Research (SSBTR) is a registered (and also both 12A & 80G certified) not-for-profit scientific society organizes an International Webinar Series Lectures on Translational Systems Biology. 

All are cordially invited. For date, time and link and other details as below:

GOOGLE MEET Link: url (https://meet.google.com/qjb-utgp-ymk)

Day: 2021-Feb-27 (Saturday)  Time: IST 17:00 Hour

# Speaker: Prof. Jan-Hendrik (Jannie) Hofmeyr
Title: The Metabolic Marketplace: How the cellular economy of supply and demand is regulated
Abstract: A central tenet of systems biology is that organisms, cells, genes and proteins are complex structures whose relationships and properties are largely determined by their functional organisation. In terms of functional organisation cellular metabolism can be regarded as a chain of coupled factories: a catabolic factory transforms nutrients into carbon skeletons and captures chemical energy and reducing power. These catabolic products serve as input to an anabolic factory that synthesizes the building blocks for macromolecular syntheses (amino acids, nucleotides, simple lipids, etc.). The factories for protein, polynucleotide, complex carbohydrate and lipid synthesis form the end of the chain and lead to growth. I show how this view of the functional organisation of the cell underlies a quantitative formalism and a general theory for understanding the cell as an integrated molecular economy of coupled supply and demand systems that have evolved regulatory mechanisms that enable them to fulfil specific functions such as control of flux or homeostatic maintenance of metabolite concentrations.
Bio-sketch:
Jan-Hendrik (Jannie) Hofmeyr is Emeritus Professor of Biochemistry and has been a member of the Biochemistry Department at the Stellenbosch University since 1975. He obtained his Ph.D. in 1986 at the University of Stellenbosch. His research of the past 40 years has been in the fields of metabolic control analysis and computational systems biology where his main focus has been the understanding of the regulatory design of metabolism. He also co-directed the Centre for Complex Systems in Transition where an additional research focus was the functional organisation that underlies cellular self-fabrication. He is a Fellow and was President of the Royal Society of South Africa, and is a member of the Academy of Science of South Africa. He is a founder member and served as Vice President of the International Society for Code Biology. 

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Durjoy Majumder, Ph.D.