Society for Systems Biology & Translational Research (SSBTR) is a registered (and also both 12A & 80G certified) not-for-profit scientific society organizes an International Webinar Series Lectures on Translational Systems Biology.
All are cordially invited. For date, time and link and other details as below:
GOOGLE MEET Link: url (https://meet.google.com/qjb-utgp-ymk)
Day: 2021-Feb-27 (Saturday) Time: IST 17:00 Hour
# Speaker: Prof. Jan-Hendrik
(Jannie) Hofmeyr
Title: The Metabolic
Marketplace: How the cellular economy of supply and demand is
regulated
Abstract: A central tenet
of systems biology is that organisms, cells, genes and proteins are
complex structures whose relationships and properties are largely
determined by their functional organisation. In terms of functional
organisation cellular metabolism can be regarded as a chain of
coupled factories: a catabolic factory transforms nutrients into
carbon skeletons and captures chemical energy and reducing power.
These catabolic products serve as input to an anabolic factory that
synthesizes the building blocks for macromolecular syntheses (amino
acids, nucleotides, simple lipids, etc.). The factories for protein,
polynucleotide, complex carbohydrate and lipid synthesis form the end
of the chain and lead to growth. I show how this view of the
functional organisation of the cell underlies a quantitative
formalism and a general theory for understanding the cell as an
integrated molecular economy of coupled supply and demand systems
that have evolved regulatory mechanisms that enable them to fulfil
specific functions such as control of flux or homeostatic maintenance
of metabolite concentrations.
Bio-sketch: Jan-Hendrik
(Jannie) Hofmeyr is Emeritus Professor of Biochemistry and has been a
member of the Biochemistry Department at the Stellenbosch University
since 1975. He obtained his Ph.D. in 1986 at the University of
Stellenbosch. His research of the past 40 years has been in the
fields of metabolic control analysis and computational systems
biology where his main focus has been the understanding of the
regulatory design of metabolism. He also co-directed the Centre for
Complex Systems in Transition where an additional research focus was
the functional organisation that underlies cellular self-fabrication.
He is a Fellow and was President of the
Royal Society of South Africa, and is a member
of the Academy of Science of South Africa. He is a founder member and
served as Vice President of the International Society for Code
Biology.
Event Photo:
---
Durjoy Majumder, Ph.D.
