Few people are capable of expressing with equanimity opinions that differ from the prejudices of their social environment. Most people are even incapable of forming such opinions." - The New Quotable Einstein
need to overcome the idea, so prevalent in both academic and
bureaucratic circles, that the only work worth taking seriously is
highly detailed research in a speciality. We need to celebrate the
equally vital contribution of those who dare to take what I call "a
crude look at the whole". - Murray Gell-Mann, Nobel Laureate in Physics,
All are cordially invited.
For Google Meet Link see below or write a mail to: email@example.com.
Please follow this page "SSBTR International Webinar Lecture Series" for up-datation.
# Speaker: Dr. Heiko Enderling, H. Lee Moffitt Cancer Centre & Research Institute, at IST 17:30 HourTitle: Integrating Computer Modeling of Cancer into Patient-specific Clinical Decision Making
Abstract: In close collaboration with experimentalists and clinicians, mathematical models that are parameterized with experimental and clinical data can help estimate patient-specific disease dynamics and treatment success. This positions us at the forefront of the advent of ‘virtual trials’ that predict personalized optimized treatment protocols. I will discuss a couple of different projects to demonstrate how to integrate calculus into clinical decision making. First, we show that a mathematical model can be calibrated from early treatment response dynamics in patients undergoing hormone therapy for prostate cancer. The learned model dynamics can then be used to forecast responses to subsequent treatment, and identify high risk patients who would benefit from concurrent therapies. In a second example, I will discuss how the pre-treatment tumor-immune ecosystem can be predictive of radiotherapy outcome, and how we can prospectively simulate treatment response dynamics to identify patient candidates for radiation dose escalation when needed, and treatment de-escalation without jeopardizing outcomes.
Bio-sketch: Dr. Heiko Enderling, an Associate Professor, H. Lee Moffitt Cancer Center & Research Institute. He is associated with Dept. of Integrated Mathematical Oncology, Dept. of Radiation Oncology, also working as Director for Education and Outreach Fellow. He is the Elected President of Society for Mathematical Biology. Before joining to Moffitt, he served as Assistant Professor, Center of Cancer Systems Biology, Tufts University School of Medicine, 2007-2013. His research interests include: Quantitative Personalized Oncology, developing calibrated and validated mathematical model driven by clinical data to aid patient-specific treatment decisions, Tumor-immune ecosystem dynamics and response to radiotherapy, and vision is to educate the next generation of interdisciplinary researchers. He was honored as Moffitt Educator of the Year 2017 and Moffitt Mentor of the Year 2020.
Speaker: Dr. Probir Kumar Dhar, Lead Scientist, SSBTR at IST 18:30
Title: A System Biology Based Dynamic Model to Limit Uncertainty in Cancer Treatment
Abstract: In present cancer treatment scenario different chemotherapeutic strategies like Maximum Tolerable Dosing (MTD), Metronomic Chemotherapy (MCT), Antiangiogenic (AAG) drug, Hematopoietic stem cell transplantation are available; however, the selection of the best therapeutic strategy for an individual patient at any particular stage of disease remains uncertain till now. Several analytical models are proposed for each of the chemotherapeutic strategies; however, no single analytical model is available that can make a comparative assessment of the long-term therapeutic efficacy among these strategies towards patient specific manner. To address this issue we developed a composite synergistic system (CSS) model. Here we have synergized the output of two models. One is based on fluid dynamics (FD) principle and another is based on vasculature growth (VG). In this developed model considered model variables are helpful for fitting of initial clinical data of individual clinical cases and successive model simulation runs may help in making therapeutic decision/prediction. Again tracking tumor growth at a regular interval of time is possible by matching the simulation output with available clinical techniques like MRI or simple blood testing. Such model may help the clinician to overcome the uncertainty in therapy design at an individual patient level.
Bio-sketch: Probir Kumar Dhar, is a Lead Investigator in SSBTR. He received his Masters' degree in Microwave Engineering and PhD degree from Jadavpur University in the field of Cancer Systems Biology. Before this present assignment, he has a teaching experience of 15 years in the area of Electronics and Communication Engineering in different institutions across India. In his credit more than 10 research articles and policy publications, which were appeared in different systems biology journals like Automatic Control of Physiological State and Function, Computational Biology Journal, Journal of Computational Systems Biology, Journal of Oncology and Translational Research. He has presented his works in different International conferences. He received and successfully completed a AICTE sponsored project MODROB [Modernization and Removal of Obsolescence] titled as 'Advancement of microwave antenna & transmission line experiment facilities for academic purposes'. His present interest involves development of a clinical software for leukemia therapy design and assessment and e-learning modules "Coding for Future Systems Biologists".
GOOGLE MEET Link: SSBTRwebinarLecture or url (https://meet.google.com/qjb-utgp-ymk)
Day: 2020-Dec-06 (Sunday) Time: IST 14:45 Hour
Speaker: Dr. Igor Balaz, University of Navi Sad at IST 15:00 Hour.
Title: Artificial Intelligence and Multiscale Modeling of Tumor Treatments
Abstract: From the perspective of systems biology tumor can be regarded as a complex adaptive system. It is a nonlinear system, composed of a number of dynamically interacting elements with complex feedbacks between them. To model such systems multiple scales should be taken into account. Molecular scale simulations can give us insight into structural, thermodynamic, kinetic and other properties of applied drugs and how those drugs interact with cell membrane and receptors. At the cellular scale, pharmacodynamics modeling simulates the efficacy and toxicity of drugs. At the tumor scale, we need to integrate findings from the molecular and cellular scale simulations with the heterogeneous and adaptable tumor structure. To model tumor adaptive dynamics and the resulting emergence of treatment resistance, we should incorporate individualized genotype and phenotype data. Finally, at the organism scale, we should use integrated PK/PD approaches to model bio-distribution and clearance of drugs, as well as whole-body physiologically based pharmacokinetic models (PBPK). The set of all possible configurations of such modeling effort is enormous. Computationally investigating all of them is not feasible approach. However, with Artificial Intelligence we can speed-up and automate the search for optimal treatment strategy. In this webinar we will discuss strategies for developing such multiscale modeling platform and how it can be integrated with artificial intelligence.
Bio-sketch: Dr. Igor Balaz is an Assistant Professor at the University of Novi Sad, Serbia. He runs a computational biophysics lab in targeting the systems biology of cancer. The work of his team blends nanomedicine, molecular modeling, mathematical modeling and artificial intelligence to search for novel drug delivery systems. He leads two multinational European projects on the use of nanomedicine in cancer treatment: EVO-NANO (Evolvable platform for programmable nanoparticle-based cancer therapies) and PACE (Platform for Rapid Development of Personalized Nanomedicine Drug Delivery Systems).
Speaker: Prof. Shubhabrata
Datta, SRM University at IST 16:00 Hour
Title: Machine Learning for Designing Hard Tissue Prostheses
Abstract: To improve the performance of the orthopedic and dental implants, i.e. to improve several properties simultaneously, the constituent biomaterials properties as well as implant structure needs to be designed judiciously. The choice of the parameters for achieving optimum performance of the systems is difficult to arrive experimentally, as the process becomes expensive and laborious. In silico approaches hold promise for searching the solutions for achieving the target performance. Among the many approaches of designing materials and structures for protheses computationally, machine learning attempts to map the hidden relationship between the variables of complex, nonlinear systems using available information of the system in a high-throughput, statistically robust, and yet physically meaningful manner. Machine learning tools, e.g. artificial neural network and neuro-fuzzy inference systems are increasingly used in the domain of informatics-based design of implants and biomaterials. In a prescriptive analytics approach for improving several properties together, many of them having conflicting objectives, the developed models are used as objective functions for optimization with genetic algorithm used in single as well as multi-objective mode.
Bio-sketch: Prof. Shubhabrata Datta, is a Research Professor in the Department of Mechanical Engineering, SRM Institute of Science and Technology, SRM University, received his PhD from Indian Institute of Engineering Science and Technology, Shibpur, India (previously known as B.E. College Shibpur) in the field of Metallurgical and Materials Engineering. He has more than three decades of teaching and research experience. His research interest is in the domain of design of materials using artificial intelligence and machine learning techniques. More than 150 publications as journals and peer-reviewed conference proceedings to his credit. Eleven of his graduate students have been conferred with PhD degree. He was bestowed with the Exchange Scientist Award from Royal Academy of Engineering, UK and worked in the University of Sheffield, UK. He also worked Dept of Materials Science and Engineering, Helsinki University of Technology, Finland, Dept of Materials Science and Engineering, Iowa State University, Ames, USA and Heat Engineering Lab, Dept of Chemical Engineering, Åbo Akademi University, Finland as Visiting Scientist. He is a Fellow of Institution of Engineers (India), Associate Editor, Journal of the Institution of Engineers (India): Series D, and editorial board member of several international journals.
Speaker: Prof. Olivier Gandrillon, Ecole Normale Superieure de Lyon at IST 13:00
Title: Toward a dynamical network view on a differentiation process
Abstract: A recent view emerged that stochastic dynamics governing the switching of cells from one differentiation state to another could be characterized by a peak in gene expression variability at the point of fate commitment. We have tested this hypothesis at the single-cell level by analyzing primary chicken erythroid progenitors through their differentiation process and measuring the expression of selected genes at six sequential time-points after induction of differentiation. In contrast to population-based expression data, single-cell gene expression data revealed a high cell-to-cell variability, which was masked by averaging. Shannon entropy was used as as a measure of the cell-to-cell variability in gene expression. Entropy values showed a significant increase, reaching a peak between 8 and 24 h, before decreasing to significantly lower values. We observed that the previous point of maximum entropy precedes an irreversible commitment to differentiation between 24 and 48 h. In conclusion, when analyzed at the single cell level, the differentiation process looks very different from its classical population average view. New observables (like entropy) can be computed, the behavior of which is fully compatible with the idea that differentiation is not a “simple” program that all cells execute identically but results from the dynamical behavior of the underlying molecular network.
Bio-sketch: Dr. Olivier Gandrillon received PhD degree in biology in 1989. After a two years post-doctoral stay at Caltech, he was appointed a permanent research position at Ecole Normale Supérieure de Lyon in 1989 and started his own team as an independent group leader in 1999 in Université Claude Bernard. He was awarded research director at CNRS in 2009. He moved back to ENS in 2015, where he is now heading a group entitled "Systems Biology of Decision Making". He has a long experience in multidisciplinary projects and interactions between Computer Science, Life Sciences and Mathematics. He is a member of the Dracula Inria team that is devoted to developing mathematical tools for multiscale modeling. He was elected director of the BioSyL research federation since 2011 when the federation was founded. He is the founder of the modeling seminar “Semovi” and of the international conference series “Integrative Post Genomics” (2001-2010) and “LyonSysBio” (since 2014). He was the co-chair of the very successful ICSB2018 conference. He co-authored 72 original publications in a very large range of different disciplinary fields.
# Speaker: Dr. Jianhua
of Pittsburgh at IST 18:00 Hour
Title : Reconstructing cell phenotypic transition dynamics from single cell data
Abstract : Recent advances in single-cell techniques catalyze an emerging field of studying how cells convert from one phenotype to another, i.e., cell phenotypic transitions (CPTs). Two grand technical challenges, however, impede further development of the field. Fixed cell-based approaches can provide snapshots of high-dimensional expression profiles but have fundamental limits on revealing temporal information, and fluorescence-based live cell imaging approaches provide temporal information but are technically challenging for multiplex long- term imaging. My lab is tackling these grand challenges from two directions, with the ultimate goal of integrating the two directions to reconstruct the spatial-temporal dynamics of CPTs. In one direction, we developed a live-cell imaging platform that tracks cellular status change in a composite multi-dimensional cell feature space that include cell morphological and texture features readily through fluorescent and transmission light imaging. We applied the framework to study human A549 cells undergoing TGF-β induced epithelial-to-mesenchymal transition (EMT). In another direction, we aim at reconstructing single cell dynamics and governing equations from single cell genomics data. We developed a procedure of learning the analytical form of the vector field F(x) and the equation dx/dt = F(x) in the Reproducing Kernel Hilbert Space. Further differential geometry analysis on the vector field reveals rich information on gene regulations and dynamics of various CPT processes.
Bio-sketch :Dr Xing received B.S. in Chemistry from Peking University, M.S. in Chemical Physics from University of Minnesota, and PhD in Theoretical Chemistry from UC Berkeley. After being a postdoc researcher in theoretical biophysics at UC Berkeley and an independent fellow at Lawrence Livermore National Laboratory, he assumed his first faculty position at Virginia Tech, then moved to University of Pittsburgh in 2015. Currently Dr Xing is an Associate Professor in the Computational and Systems Biology Department, School of Medicine, a founding member of Center for Systems Immunology, and an affiliated faculty member of Department of Physics, University of Pittsburgh. He is also an affiliated member of University of Pittsburgh Hillman Cancer Center. Dr Xing’s research uses statistical and chemical physics, dynamical systems theory, mathematical/computational modeling in combination with quantitative measurements to study the dynamics and mechanics of biological processes. Recently his lab focuses on reconstructing information of cell phenotypic transition dynamics from live cell time-lapse images and snapshot high-throughput single cell data. Another related direction is to study how three-dimensional chromosome structure and dynamics, epigenetic modification, and gene regulation are coupled.
# Speaker: Dr. Mohit
Kumar Jolly, Indian
Institute of Science, Bangalore at IST 19:00 Hour
Title : Systems
biology of cancer metastasis: how do cancer cells coordinate,
communicate, and cooperate?
Abstract : Metastasis (the spread of cancer cells from one organ to another) and therapy resistance cause above 90% of all cancer-related deaths. Despite extensive ongoing efforts in cancer genomics, no unique genetic or mutational signature has emerged for metastasis. However, a hallmark that has been observed in metastasis is adaptability or phenotypic plasticity – the ability of a cell to reversibly switch among different phenotypes in response to various internal or external stimuli. Phenotypic plasticity has also been recently implicated in enabling the emergence of resistance for many cancers across multiple therapies. However, a mechanistic understanding of these processes from a dynamical systems perspective remains incomplete. This talk will describe how mechanism-based mathematical models for phenotypic plasticity can enable our improved understanding of cellular decision-making at individual and population levels from these perspectives: a) Multistability (how many cell states exist en route?), b) Reversibility (do cells come across a ‘tipping point’ at specific time and/or dose of inducers beyond which they do not revert?), and c) Cell-cell communication (how do cells affect tendency of their neighbors to exhibit plasticity?). Collectively, our work highlights how an iterative crosstalk between mathematical modeling and experiments can both generate novel insights into the emergent nonlinear dynamics of cellular transitions and uncover previously unknown accelerators of metastasis and therapy resistance.
Bio-sketch : Dr. Mohit Kumar Jolly leads the Cancer Systems Biology group at the Centre for BioSystems Science and Engineering, Indian Institute of Science. He has made seminal contributions to decoding the emergent dynamics of epithelial-mesenchymal plasticity (EMP) in cancer metastasis, through mathematical modeling of regulatory networks implicated in EMP; his work has featured on the cover of Journal of Clinical Medicine, Cancer Research, and Molecular and Cellular Biology, and he won the 2016 iBiology Young Scientist Seminar Series – a coveted award for communicating one’s research to a diverse audience. Currently, his lab focuses on decoding mechanisms and implications of non-genetic heterogeneity in cancer metastasis and therapy resistance, with specific focus on mechanism-based and data-based mathematical modeling in close collaboration with experimental cancer biologists and clinicians. He is an elected fellow of Indian National Young Academy of Sciences (INYAS), and serves as Secretary of The International Epithelial-Mesenchymal Transition Association (TEMTIA).
Dr. Durjoy Majumder
Organizing Secretary of the SSBTR Webinar Lecture Series