# Speaker : Professor Ernst Titovets IST : will be announced
Title : Novel Nanofluidic Mechanism and Computational Model of the Brain Water Metabolism
Abstract : Brain water metabolism ensures the processes of cellular communication, transit of the signaling molecules, neurotransmitters, cytokines and substrates, participates in the clearance of pathogenic metabolites. Many neurological conditions that present serious clinical problems arise from altered fluid flow (e.g. Alzheimer’s disease, idiopathic normal pressure hydrocephalus, migraine, traumatic brain injury and stroke). At present, the orthodox theory fails to explain the accumulated experimental evidence and clinical data on the brain water metabolism. Modeling becomes an important approach to testing current theories and developing new working mechanisms.
A novel computational model of brain water metabolism has been developed and explored. Using an interdisciplinary approach the long-recognized nano-dimentionality of the brain interstitial space is viewed as a nano-fluidic domain with the fluid flow there governed by the slip-flow principles of nano-fluidics. Aquaporin-4 (AQP4) of the astrocyte endfeet membranes ensures kinetic control over water movement across the blood-brain barrier. The pulsatory intracranial pressure presents the driving force behind the transcapillary water flow. The model demonstrates good predictability in respect to some physiological features of brain water metabolism and relevance in explaining clinical conditions. The model may find its use in neuro-biological research, development of the AQP4-targeted drug therapy, optimization of the intrathecal drug delivery to the brain tumours, in a research on a broad spectrum of water-metabolic-disorder-related conditions.
Bio-sketch : Professor Ernst Titovets, M.D., Ph.D. holds a position of Professor at the Department of Neurosurgery, Republican Research and Clinical Center of Neurology and Neurosurgery, Minsk, Belarus. He is a researcher, author, translator and interpreter was born in Krasnoyarsk, Siberia. He graduated from the Minsk State Medical Institute and undertook post-graduate research in biochemistry. He earned his Ph. D. degree from the Academy of Sciences of Belarus for his research on endergonic transport of Ca++ by the mitochondria. His Doctor of Sciences Degree in biology he obtained from the St. Petersburg State University, Russia for his pioneering research on the biochemical action mechanism of new amino derivatives of orthobenzoquinone. Appointed to a number of scientific research councils, he has authored or co-authored four research books, 14 patents and over 400 research papers and as an interpreter, he translated three books. As an Author, he wrote a book Oswald: Russian Episode that has appeared in three editions. The book presents an in deep historic investigation of life of Lee Harvey Oswald, an alleged assassin of the President John Kennedy. Currently he is concentrated on a research on brain water metabolism and related issues conducted from the nanofluidic approach. He is a principal researcher, at the Republican Research and Clinical Centre of Neurology and Neurosurgery in Minsk, Belarus where he heads a scientific research group.